Tenofovir: Uses, Dosage, Safety & FAQs

If you’ve been prescribed Tenofovir, you probably have a lot of questions. Is it safe? How do you take it? Does your weight matter? Below you’ll find straight‑forward answers that let you use the drug with confidence.

When is Tenofovir prescribed?

Tenofovir comes in two main forms: Tenofovir disoproxil fumarate (TDF) and Tenofovir alafenamide (TAF). Both block the virus that causes HIV, and both also fight chronic hepatitis B. Doctors choose TDF when they need a strong, well‑studied option, especially for people with high viral loads. TAF is newer, gives the same antiviral power, but delivers less drug to the kidneys and bones, so it’s a better pick for patients with kidney issues or bone loss.

How to dose Tenofovir safely

Standard adult doses are simple: 300 mg of TDF once daily or 25 mg of TAF once daily. The pill is usually taken with water, with or without food – just stick to the same routine each day. For kids and teens, doctors calculate the dose based on body weight (mg per kilogram), because a child’s metabolism is faster. That’s why a weight‑based calculator can be handy when you’re asking a pharmacist for the right pediatric dose.

Kidney health matters a lot with Tenofovir. TDF can raise creatinine levels, especially if you have pre‑existing kidney disease or take other nephrotoxic drugs. Your doctor will check blood work before you start and then every few months. If your kidneys aren’t handling the drug well, they might lower the dose or switch you to TAF, which stays out of the kidneys more.

Bone density is another concern. Long‑term TDF use has been linked to a small drop in bone mineral density. If you’re already at risk for osteoporosis, ask your doctor whether TAF is a safer choice. Adding calcium and vitamin D, and staying active, can help keep your bones strong while you’re on therapy.

Drug interactions are easy to miss but important. Tenofovir doesn’t mix well with certain antivirals, some antibiotics, and medicines that affect kidney function, like non‑steroidal anti‑inflammatory drugs (NSAIDs). Always tell your pharmacist about every prescription, over‑the‑counter pill, and supplement you take. A quick check can prevent a nasty reaction.

Side effects are usually mild. Some people feel nausea, headache, or a little fatigue the first few days. Those symptoms often fade as your body gets used to the medication. If you notice sudden swelling, severe stomach pain, or a rash, call your doctor right away – those could be signs of a rare, but serious, reaction.

Remember, the best way to stay on track is to pair Tenofovir with regular medical follow‑up. Bring your latest lab results to each appointment, keep a medication diary, and never skip doses without talking to your provider. Consistency keeps the virus suppressed, protects your liver, and reduces the chance of resistance.

Bottom line: Tenofovir is a powerful, once‑daily pill that works for HIV and hepatitis B. Use the standard adult dose unless your doctor says otherwise, watch your kidney labs, and pick the right formulation for your bone health. With proper monitoring, you can stay healthy and keep the virus under control.